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Ptah

(33,842 posts)
Mon Jun 30, 2025, 08:22 PM Jun 30

After six or eight hospital stays,

four ambulance rides, twenty or so doctors a few wound care nurses, several MRIs, multiple x-rays and about ninety prescriptions,
my daughter has had her first day at work in almost two years!


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Ptah

(33,842 posts)
5. It's actually a remarkable medical accomplishment.
Mon Jun 30, 2025, 09:04 PM
Jun 30

Banner, TMC, St Mary's, a rehab stint.
Dermatologist, Spinal surgeon, Rheumatologist, and more.

A little background: https://www.democraticunderground.com/114234649

I am pleased with the care and outcome.

Kali

(56,337 posts)
7. I apologize
Mon Jun 30, 2025, 09:18 PM
Jun 30

My various little journeys into medical misery are NOTHING compared to what she has gone through. Was just indulging in a little 2 month pity party this week. Perspective! Sorry I never saw that thread and I command that she co tntinues to do well.

Figarosmom

(7,251 posts)
6. I hope she gets tbrough
Mon Jun 30, 2025, 09:11 PM
Jun 30

The first day back with little trauma and isn't completely worn out when she gets home. First days back are hard.

wendyb-NC

(4,417 posts)
11. Glad she's able to finally get back to work
Mon Jun 30, 2025, 10:02 PM
Jun 30

She went through quite an ordeal. I hope that she continues to get well, and also get to enjoy her life, immensely, for many, many years to come in great health.

NNadir

(36,212 posts)
12. That sounds like a nasty syndrome. I never heard of it, but looked it up.
Mon Jun 30, 2025, 10:12 PM
Jun 30

It seems to be an autoimmune disease from a cursory look at this paper:

Maverakis, E., Marzano, A.V., Le, S.T. et al. Pyoderma gangrenosum. Nat Rev Dis Primers 6, 81 (2020)

When I called this paper up and downloaded it - unfortunately it requires access, which I have, but it is not generally open to the public - I came across another paper that is open access:

Moura, R.R., Brandão, L., Moltrasio, C. et al. Different molecular pathways are disrupted in Pyoderma gangrenosum patients and are associated with the severity of the disease. Sci Rep 13, 4919 (2023)

It probably requires a modicum of scientific knowledge to understand the paper, but if I can say anything, we do live (or have lived, as science is being actively attacked) in the golden age of molecular biology, particularly with respect to immunology, and I hope and suspect that your daughter's return to work is an outgrowth of such knowledge.

I have been around lupus patients in connection with a family I knew when I was a young man, a similar (from what I can tell) autoimmune disease, and from that, I know it can be rough.

I'm sure I speak for everyone here in wishing you and your daughter the best.

Ptah

(33,842 posts)
14. For me, I am the most impressed with Fetal Bovine Dermal Repair Scaffold
Mon Jun 30, 2025, 10:39 PM
Jun 30
Fetal Bovine Dermal Repair Scaffold Used for the Treatment of Difficult-to- Heal Complex Wounds
https://pubmed.ncbi.nlm.nih.gov/25876169/
Results: Wounds treated with the acellular fetal bovine dermis included chronic diabetic wounds, venous wounds, and pressure ulcers, as well as wounds caused by trauma and surgery. Additionally, the patients treated had comorbidities commonly associated with recalcitrant wounds. Of the wounds evaluated in this study, 75.9% successfully healed; 63.8% reepithelialized, and 12.1% were closed with a skin graft subsequent to treatment. Notably, the majority (58.6%) of the wounds reepithelialized by 12 weeks following a single application of the dermal repair scaffold. In the subset of challenging wounds with exposed tendon/bone, 80.8% of the wounds were treated successfully (61.5% reepithelialized, and 19.3% were skin grafted), indicating the successful regeneration and reepithelialization of new vascularized tissue by fetal dermal collagen in relatively avascular wound defects.

Conclusion: The acellular fetal bovine dermal repair scaffold can be used as part of an effective treatment regimen to heal complex wounds with exposed tendon/bone caused by varying etiologies. The product actively participates in the generation of a new, vascularized tissue capable of reepithelializing, or successfully supporting, a split-thickness skin graft in defects where initial grafting or living skin substitutes are not viable options. .
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